PRESSURE REGULATORS (BPRs)
- Proven Outgassing Protection / Flow-Independent Pump Preload for Greater Pump Efficiency / 5 to 1,000 psi Cartridges and Assemblies Available
Scientific® offers a full line of factory preset back pressure regulators,
designed to enhance system performance through outgassing prevention and
improved pump check valve efficiency.
Small gas bubbles often form as solvent moves from the high pressure environment of an HPLC column to the low pressure environment leading to the detector. This outgassing can cause erratic baseline readings and loss of sensitivity. Placing an Upchurch Scientific BPR after the detector provides an excellent, low-cost method for preventing this problem by maintaining enough back pressure on the mobile phase to keep gases dissolved in solution.
A back pressure regulator can also be used as a pump preload for low and fluctuating pressure applications. Many of today's pumps require a steady back pressure to function properly. Install an Upchurch Scientific BPR (usually 500 - 1,000 psi) between the pump and the injector to enhance pump performance. Caution: Do not exceed the maximum operating pressure of your system - please refer to the operating manuals for your system components before choosing the appropriate BPR.
|Choose from our line of PEEK and Stainless Steel BPR Assemblies, each complete with a replaceable, factory preset cartridge.Upchurch Scientific BPR Assemblies create incremental back pressures ranging from 5 to 1,000 psi (0.3 to 69 bar). For low pressure applications we recommend our 5 and 20 psi PEEK BPR Assemblies. These products are ideal for eliminating back pressure fluctuation in systems that have delicate components requiring a low pressure threshold. Since these two preset assemblies are extremely sensitive, they are sold as assemblie||BACK PRESSURE REGULATOR ASSEMBLY|
line of back pressure regulators includes:
and 20 psi Assemblies
- 40, 75, 100, 250, 500, 750 and 1,000 psi Cartridges and Assemblies
- PEEK™ and Stainless Steel BPR Holders
- High Pressure Adjustable BPR for pressures between 2,000 and 5,000 psi
- Ultra Low Volume BPRs set to 100 and 500 psi
Scientific® BPR Cartridges have a maximum internal volume of 146µL. The
cartridge bodies are manufactured from inert PEEK™ and Tefzel® (ETFE)
polymers. Internal components are manufactured from PEEK, highly
fluorinated elastomer and gold-plated stainless steel. These cartridges
create back pressures from 40 to 1,000 psi (2.8 to 69 bar) - all
independent of flow except as noted below.
Please Note: the recommended operating flow rate range for our BPR Cartridges is 0.1mL - 10mL/min. Within this range, the amount of back pressure created by the BPR Cartridges and Assemblies will not vary more than ±10%. Lower or higher flow may result in larger pressure fluctuations.
|Only 10% fluctuation in pressure generally occurs with flow rates of 01 - 10mL/min. Lower or higher flow rates will lead to greater fluctuations in pressure,||The biocompatible P-880 High Pressure Adjustable BPR offers the flexibility to adjust your system back pressure between 2,000 and 5,000 psi (138 and 345 bar), independent of the flow. To achieve the desired back pressure setting, simply turn the thumbscrew while monitoring your system pressure. Because this product creates such high back pressure, please check system component specifications prior to using to avoid damaging any sensitive components.|
|Upchurch Scientific P-465 PEEK and U-469 Stainless Steel BPR Holders work with any of our replacement BPR Cartridges. Each holder comes complete with fittings for 1/16" OD tubing. The U-469 Holder is surface-treated to prevent galling, a potential problem with large, threaded metal parts.||
Pressure Rating 3,000 psi (207 bar) (1) Pressure rating 4,000 psi (276 bar) (2)
(1) Using PEEK tubing and supplied fittings (2) Using stainless steel tubing and supplied fittings
|Please Note: these PEEK Back Pressure Regulator Holders are designed to allow each cartridge to operate at its stated pressure setting when tightened to 20 in. lbs. of torque. To approximate this level of torque, first finger tighten the Holder, then tighten an additional 1/8-1/4 turn with the supplied wrenches.|
|BPR ASSEMBLIES WITH PEEK HOLDER|
|P-790||5 psi (0.3 bar) BPR cartridge with PEEK holder (1)||134µL|
|P-791||20 psi (1.4 bar) BPR cartridge with PEEK holder (1)||134µL|
|P-785||40 psi (2.8 bar) Bill cartridge (P-761) with PEEK holder (2)||131µL|
|P-786||75 psi (5.2 bar) BPR cartridge (P-762) with PEEK holder (2)||131µL|
|P-787||100 psi (7 bar) BPR cartridge (P-763) with PEEK holder (2)||131µL|
|P-788||250 psi (17 bar) BPR cartridge (P-764) with PEEK holder (3)||102µL|
|P-789||500 psi (34 bar) BPR cartridge (P-765) with PEEK holder (4)||96µL|
|P-455||1,000 psi (69 bar) BPR cartridge (P-796) with PEEK holder (4)||89µL|
|BPR ASSEMBLIES WITH STAINLESS STEEL [SST] HOLDER|
|U-605||40 psi (2.8 bar) BPR cartridge (P-761) with SST holder (5)||129µL|
|U-606||75 psi (5.2 bar) BPR cartridge (P-762) with SST holder (5)||129µL|
|U-607||100 psi (7 bar) BPR cartridge (P-763) with SST holder (5)||129µL|
|U-608||250 psi (17 bar) BPR cartridge (P-764) with SST holder (5)||99µL|
|U-609||500 psi (34 bar) BPR cartridge (P-765) with SST holder (5)||93µL|
|U-610||750 psi (52 bar) BPR cartridge (P-795) with SST holder (4)||91µL|
|HIGH PRESSURE ADJUSTABLE BPR ASSEMBLY|
|P-880||2,000 - 5,000 psi (138-345 bar) Adjustable BPR (7)||9µL|
|P-761||40 psi (2.8 bar) BPR cartridge||
|P-762||75 psi (5.2 bar) BPR cartridge||Tan Yellow||125µL|
|P-763||100 psi (7 bar) BPR cartridge||Tan Red||125µL|
|P-764||250 psi (17 bar) BPR cartridge||Tan White||95µL|
|P-765||500 psi (34 bar) BPR cartridge||Tan Green||98µL|
|P-795||750 psi (52 bar) BPR cartridge||Black Blue||87µL|
|P-796||1,000 psi (69 bar) BPR cartridge||Black Green||83µL|
|U-469||High Pressure Stainless Steel BPR holder (6)|
Comes complete with P-200 ETFE Flangeless Ferrules and P-215 ETFE
(2) Comes complete with P-200 ETFE Flangeless Ferrules. P-215 ETFE Flangeloss Nuts and wrenches. (3) Comes complete with P-200 ETFE Flangeless Ferrules. P-235 PEEK Flangeless Nuts and wrenches. (4) Comes with LT-115 Super Flangeless PEEK Nuts, P-250 Super Flangeless Ferrules and wrenches. (5) Comes complete with P-200 ETFE Flangeless Ferrules and P-201 Delrin® Flangeless Nuts (6) Comes with F-300 PEEK Two-Piece Fingertight Fittings.(7) Comes with F-120BLK One-Piece Finger[ight Fittings.
|ULTRA_LOW VOLUME BPRs|
|Our Ultra-Low Volume Back Pressure Regulators (BPRs) were developed to minimize swept volume, which is especially important for multidetector applications. With a maximum swept volume of only 6µL (1) , it is nearly impossible to detect these BPRs as part of your fluid pathway (please see "Difficult to Detect" below for more details). And because the flow path is completely polymeric, you are assured of biocompatibility.|
Ultra-Low Volume BPRs are available with back pressure settings of 100 and
500 psi (see Specifications Table). These units can be operated above and
below their flow-rate recommendations; however, the resulting back
pressure will differ from that set at the factory.
A set screw allows adjustments to the back pressure rating. Take care to ensure the resulting back pressure does not exceed the recommended pressure range listed in the Specifications table or that of your system components.
To minimize the swept volume added to your flow path, we recommend trimming the length of the attached tubing.
Please Note: Our Ultra-Low Volume Back Pressure Regulators cannot be used as check valves due to their unique internal design. Try our MicroVolume Inline Check Valve.
(1) The maximum internal swept volume listed above is for the back pressure regulator only and does not include the volume of the attached tubing lines.
|DIFFICULT TO DETECT|
sample of identical concentration was injected and data wascollected from
two detectors simultaneously. In the first examplebelow, the two detectors
were separated by 42cm of.010" ID tubing,and in the second example
they were separated by the UpchurchScientific® Ultra-Low Volume BPR with
60cm of .010" ID PEEK™
tubing attached. As the data indicates, the presence of the BPRis barely detectable!
|Peak Asymmetry||Peak Width at 1/2 Height|
|I. Detectors = 300µL/min - Column = 2.0mm ID x 15cm|
|II. Detectors with M-410 Ultra-Low Volume BPR and 60cm of.010" ID tubing between them:|
|Data supplied by Gilson, Inc.|
|ULTRA-LOW VOLUME BPR SPECIFICATIONS (1)|
|Back Pressure Setting||Flow Rate Recommendations||Recommended Pressure Range||1/16" OD Tubing|
|M-410||100psi (2) Optimal:
(7 bar) (2) Max.:4mL/min
|40-150psi (3-10 bar)||PEEK,.010"ID|
(34bar) (2) Max.:4mL/min
|250-525psi (17-36 bar)||PEEK,.O10"ID|
|M-415||100 psi (2) Optimal:
(7 bar) (2) Max.:4mL/min
|40-150psi (3-10 bar)||Teflon®, .010" ID|
(7 bar) (3) Max.:10mL/min
|40-150psi (3-10 bar)||PEEK,.020"ID|
All data generated using water at room temperature.
(2) Set at a flow rate of 0.5 mL/min (3) Set at a flow rate of 5 mUmin.
- Prevent System Overpressurizntion
Scientific Pressure Relief Valves are ideal for preventing system
over-pressurization. These products protect system components by diverting
fluid flow out of the tee when pressure exceeds the set limit. Choose
between our preset 100 psi (7 bar) and 5 psi (0.3 bar) assemblies, both
shipped with our Flangeless Fittings. The 100 psi version is a good,
general purpose valve, while the 5 psi version is perfect for protecting
syringe and peristaltic pump systems. The void
volume of both relief valves is low due to the small .020" (.50mm)
thru-holes in the valve tee body.
If you wish to have the Pressure Relief Valve open at a different pressure than 5 or 100 psi, simply combine one of the other replacement Back Pressure Regulator Assemblies with the P-61 2 Pressure Relief Valve Tee. Choose the P-612S for larger bore tubing and higher flow applications.
|ULTRA-LOW VOLUME BPRs|
|M-410||100 psi (7 bar) Low Flow, with PEEK Tubing (.010" ID x 1/16" OD)|
|M-412||500 psi (34 bar) Low Flow, with PEEK Tubing (010" ID x 1/16" OD)|
|M-420||100 psi (7 bar) High Flow, with PEEK Tubing (020" ID x 1/16" OD)|
|PRESSURE RELIEF VALVES|
|U-455||5 psi (0.3 bar) Pressure Relief Valve(1) for 1/16" OD tubing||148µL|
|U-456||100 psi (7 bar) Pressure Relief Valve(2) for 1/16" OD tubing||139µL|
|P-612||Pressure Relief Valve Tee(1) for 1/16" OD tubing||14µL|
|P-612S||Pressure Relief Valve Tee(3) for 3/16" OD tubing||348µL|
|(1) Comes with P-201/P-200 Flangeless Fittings (2) Comes with P-201/P-200 Flangeless Fittings and wrenches. (3) Comes with P-133/P-132 Flangeless Fittings|
LUER INLINE CHECK VALVE
- Check Valve Protection with Luer Convenience / Automatically Opens When Engaged
CARTRIDGE CHECK VALVES
Less than 150µL Internal Volume / Low Cracking Pressures (1)
Our Quick-Stop Luer Check
Valve is designed to provide inline luer connect/ disconnect convenience
without the mess and hazard of spills. Just insert the valve into your
inline tubing using standard 1/4-28 flat-bottom fittings. The check valve
is automatically opened once the luer connection is engaged, allowing flow
in either direction. Disconnecting the luer union causes the check valve
The P-696 Quick-Stop Luer Check Valve Assembly is comprised of two halves: P-655 Male Luer-to-Female 1/4-28 Port; and the P-697 Quick-Stop Luer Check Valve. The flowpath of both is made of PEEK™ polymer. The P-697 also includes check valve components made of gold-plated stainless steel and perfluorelastomer.
The new P-698 and P-699 offer bulkhead-mounting options to this line of handy products.
Scientific® cartridge-style Inline Check Valves are designed to limit
flow to one direction. These assemblies withstand system pressures of
1,000 psi (69 bar). If the accompanying Flangeless Fittings are replaced
with Super Flangeless™ Fittings, the Check Valve Assemblies will hold to
higher pressures in the reverse direction.(2) If you prefer Fingertight
Fittings, try an Inline Check Valve Cartridge with the U-469 Stainless
Steel High Pressure Holder.Try our CV-3010 Assembly and CV-3011
Cartridge, designed specifically for degassing (sparging) lines to prevent
solvent backup if the sparging gas runs out. This check valve will prevent
potential solvent cross-contamination and damage to the gas regulating
The cracking pressures for the Inline Check Valve Cartridges are 1.5 psi (.10 bar) for the CV-3001 and 3 psi (.21 bar) for the CV-3011.
Please Note: The CV-3001 Cartridge incorporates a gold-plated stainless steel spring and a perfluoroelastomer seal, while the CV-3011 contains a standard stainless steel spring and an ethylene propylene seal.
(1) Pressure at which valve opens for flow in the direction of the arrow.
(2) These Inline Check Valve Assemblies should not be subjected to pressures above 3,000 psi (207 bar).
|QUICk-STOP LUER CHECK VALVE|
|P-696||Quick-Stop Luer Check Valve Assembly 127NL Includes (1) P-697 and (1) P-655 Luer||127µL|
|P-697||Quick-Stop Lear Check Valve||107µL|
|P-698||Bulkhead Quick-Stop Luer Valve Assembly Includes (1) P-699, (1) P-666 Luer' and (1) nut/lock washer set||127µL|
|P-699||Bulkhead Quick-Stop Luer Valve Includes (1) nut/lock washer set||107µL|
|INLINE CARTRIDGE CHECK VALVES|
|CV-3000||Inline Check Valve Assembly (1) for 1/16" OD tubing||96µL|
|CV-3001||Inline Check Valve Cartridge for CV-3000||91µL|
|CV-3010||Inline Check Valve Assembly (2) for 1/8" OD tubing||100µL|
|CV-3011||Inline Check Valve Cartridge for CV-3010||92µL|
|(1) Comes with P-215/P-200 Flangeless Fittings CV-3001 Cartridge and wrenches. (2) Comes with P-315/P-300 Flangeless Fittings. CV-3011 Cartridge and wrenches.|
1/4-28 INLINE CHECK VALVES
(1) Pressure at which valve opens for flow in the direction of the arrow
these Upchurch Scientific® Inline Check Valves to any 1/4-28 flatbottom
port. Then thread your 1/4-28 flat-bottom fitting into the check valve to
connect the tubing. Once installed, the spring-actuated sealing system
eliminates back flow, preventing upstream contamination or damage. In
addition, the unique design of this product eliminates the additional
tubing cuts and connections required to install conventional inline check
At a low cracking pressure of only 3 psi (.21 bar), our CV-3315 and CV-3316 Check Valves are well suited for syringe-pump and vacuum systems. The cracking pressure of our CV-3301 and CV-3302 Check Valves is 15 psi (1.0 bar)
of these valves are constructed of materials offering excellent chemical
resistance: PEEK™, Kel-F®, PTFE Teflon® (CV-3301 and CV-3302 only),
stainless steel or gold-plated stainless steel springs, and
Our standard 1/4-28 Inline Check Valves accommodate 1/32", 1/16", 1/8" and metric (1.0-3.Omm) OD tubing, depending on the fittings used. Select from Upchurch Scientific's broad line of Flangeless, Super Flangeless™ and VacuTight™ Fittings respectively. All four valves have a .020" thru-hole.
10-32 MICRO-VOLUME INLINE CHECK VALVE
- Nonmetallic and Biocompatible / Cracking Pressure
|With a swept
volume of only 7.4µL, the Upchurch Scientific Inline Micro-Volume Check
Valve is perfect for very low flow path volume applications, such as
delivery to lab-on-a-chip, single-cell analysis and micro-or nano-LC
post-column derivitization. Once installed, this check valve prevents back
flow and the potential for contamination or damage to sensitive upstream
equipment. The Micro-Volume Inline Check Valve is made of biocompatible
and chemically resistant PEEK polymer and perfluoroelastomer, making it
well suited for biological and corrosive fluid applications.
Connect tubing to the check valve's 10-32 coned internal ports using 10-32 threaded polymer Fingertight or SeaITight™ Fittings. Connect capillary tubing using optional ferrules or our NanoTight Fittings and Tubing sleeves.
|INLINE CHECK VALVES SPECIFICATIONS|
|Swept Volume||Max. Pressure Rating (1)||Black Pressure Created (2)|
|CV-3301, CV-3302||20µL||2,000 psi (138 bar)||54 psi (3.1 bar)|
|CV-3315, CV-3316||16µL||2,000 psi (138 bar)||10 psi (0.7 bar)|
|Nonmetallic 10-32 Micro-Volume|
|CV-3500||7.4µL||3,000 psi (207 bar)||25 psi (1.7 bar)|
|(1) These products will withstand higher pressures. However, going higher than the stated maximum pressure rating may cause future performance problems. (2) At 50mL/min with room temperature water as the solvent.|
|Bild / Artikelnummer||Beschreibung||Cracking Pressure (1)|
|CV-3301||Inlet Check Valve, 1/4-28M to 1/4-28F (2)||15 psi (1.0 bar)|
|CV-3302||Outlet Check Valve, 1/4-28M to 1/4-28F (2)||15 psi (1.0 bar)|
|CV-3315||Inlet Check Valve, 1/4-28M to 1/4-28F||3 psi (0.2 bar)|
|CV-3316||Outlet Check Valve, 1/4-28M to 1/4-28F (2)||3 psi(0.2 bar)|
|NONMETALLIC 10-32 MICRO-VOLUME INLINE CHECK VALVE|
|CV-3500||Inlet/Outlet Check Valve, 10-32F to 10-32F (2)||8 psi (0.6 bar)|
1/4-28 AND 10-32 INLINE CHECK VALVES
Nonmetallic and Biocompatible / Low Cracking Pressure
Scientific® Inline Check Valves provide excellent back-flow protection
for sensitive equipment along with outstanding chemical resistance only
available from PEEK™ polymer and perfluoroelastomer. Metalfree
composition makes these check valves perfect for use with corrosive fluids
or biological samples.
These check valves function well in both low and high pressure applications. Low internal volume also allows them to be used in areas where flow path volume is important; however, higher flow rates can pass through with very little pressure drop. All six Nonmetallic Inline Check Valves have a.020" thruhole (swept volumes shown in the Specifications table). All six also feature a springless design with 1 psi (.07 bar) cracking pressure.
Direct-connect the CV-3320 or CV-3321 to any 1/4-28 flat-bottom port for trouble-free back flow protection. If you are using a pump after your analytical column, consider placing a CV-3330 Check Valve after the column to prevent fluid from the post-column pump from flowing backwards through the column. This product also serves as an excellent nonmetallic alternative to our CV-3010 in sparging applications, where the mobile phase may be corrosive to the stainless steel or ethylene-propylene components inside the CV-3010 assembly. The configuration of the CV-3335 Inlet and CV-3336 Outlet Check Valves allows tubing larger than 1/16" OD (up to 1/8") to be connected into a 10-32 coned internal port. Use both of these check valves when attaching a largervolume sample loop to an analytical-scale injection valve. This setup limits the flow of the sample into the loop to one direction, minimizing back flow and sample carry-over. The CV-3340 is useful in virtually any high pressure fluid pathway using 1/16" or smaller OD tubing, where limiting the direction of flow is desirable. The 1/4-28 flat-bottom internal ports in our Nonmetallic Inline Check Valves can accommodate 1/32", 1/16", 1/8" and metric (1.0 - 3.0 mm) OD tubing, depending on the fittings used. Select from the broad line of Upchurch Scientific® Flangeless, Super Flangeless™ and VacuTight™ Fittings respectively.
The 10-32 coned internal ports are compatible with standard 10-32 threaded polymer Fingertight and SeaITight" Fittings metal fittings are not recommended as they may damage the ports. These ports can also accommodate NanoTight" Fittings and Tubing Sleeves (page 38) to connect capillary tubing.Tighten check valves with external threads into the appropriate receiving port using a 9/16" wrench" (1 /4 turn past finger tight) before connecting tubing and fittings into the internally threaded end.
|NONMETALLIC 1/4-28 and 10-32 INLINE CHECK VALVES|
|Artikelnummer||Beschreibung||Cracking Pressure (1)||Bild|
|CV-3320||Inlet Check Valve, 1/4-28M to 1/4-28F(2)||1 psi (.07 bar)|
|CV-3321||Outlet Check Valve, 1/4-28M to 1/4-28F(2)||1 psi (.07 bar)|
|CV-3330||1 psi (.07 bar)|
|CV-3335||Inlet Check Valve, 1/4-28F to 10-32M(2)||1 psi (.07 bar)|
|CV-3336||Outlet Check Valve, 1/4-28F to 10-32M(2)||1 psi (.07 bar)|
|CV-3340||Inlet/Outlet Check Valve, 10-32F to 10-32F(2)||1 psi (.07 bar)|
|(1) Pressure at which valve opens for flow in the direction of the arrow. (2) M = Male (external) threads, F= Female (internal) threads.|